Spatial Visualisation Tool for RNAi and Oligonucleotide-Based Therapies

Multi-omics Spatial Biodistribution Visualisation Tool for RNAi and Oligonucleotide-Based Therapies

RNA interference (RNAi) is a naturally occurring cellular mechanism to regulate gene expression. RNAi-based therapeutics leverage the natural cellular mechanism of RNAi to modulate target gene expression by delivering synthetic small RNAs, such as small interfering RNA (siRNA), Antisense Oligo (ASO) and microRNA (miRNA). A thorough understanding of biodistribution, functional efficacy, as well as on-target and off-target deliveries of the therapy is critical for successful development of these therapeutics.

RNAscope™ in situ hybridization assay guides to visualize changes in targeted cells and tissues with spatial context using both protein and RNA biomarkers. miRNAscope™ and RNAscope™ Plus assays provide spatial and cell-specific information about therapeutic biodistribution of small RNAs and their functional efficacy within intact tissues from animal models and patient biopsies. We use proprietary oligo probes designed to target short RNAs and mRNAs in conventional FFPE, frozen tissues, or cultured cells.

Learn more about miRNAScope

Presented by Dr. Alpana Kumari, Ph.D.,

Biopharma Business Dev. Manager ACD, a Bio-Techne brand

Facilitated by Dr. Behnaz Aghaei, Ph.D.,

Product and Market Development Manager, Invitro Technologies

Q&A with Dr. Amrita Roy, Ph.D.,

Product Manager ACD, a Bio-Techne brand