Intragenic Regulation Differentiates Latency in HTLV-1 & HIV-1 - Prof Satou

The Kirby Institute is a leading global research institute dedicated to the prevention and treatment of infectious diseases, with a particular focus on HIV, viral hepatitis and sexually transmissible infections. Our research is undertaken across a spectrum that ranges from laboratory studies, through clinical trials of preventative and therapeutic treatments, to public health surveillance and impact evaluation.

Kirby Institute

Professor Yorifumi Satou will present his work on intragenic regulation at the Kirby Institute Seminar Series

Online and Berg Family Foundation Seminar Room, Level 6, Wallace Wurth Building, Kensington Campus, UNSW Sydney

Kirby Institute Seminar Series

​​​​​​​​​​​​​​The Kirby Institute Seminar Series is a research seminar series that has been running since 2002.

HTLV-1 and HIV-1 share genomic features but differ in latency. Dr Satou and his team have identified an intragenic silencer in HTLV-1 that recruits RUNX1 to suppress expression. The mutation of the silencer boosts replication, and its insertion into HIV-1 reduces production. This highlights a key mechanism regulating retroviral latency and persistence, which Dr Satou will discuss in this seminar.

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