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RADIATION THERAPY FOR HEAD & NECK CANCER

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The Harry Perkins Institute of Medical Research

6 Verdun Street

Nedlands, WA 6009

Australia

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Seminar on radiation therapy for head and neck cancer with two speakers

Supported by the WA Department of Health, Cancer and Palliative Care Network


Development of a predictive adaptive radiotherapy approach to head and neck cancer

Presenter: Elizabeth Brown, Radiation Oncology Department, Princess Alexandra Hospital, Brisbane

Objectives
Head and neck cancer patients can experience considerable anatomical change throughout
chemoradiation. This can have a detrimental effect on the radiotherapy plan resulting in under or over dosing
of tumour volumes and critical structures. Adaptive radiotherapy (ART) accounts for this through replanning,
however it is a resource intensive process. Consequently, patients likely to require ART should be identified. The
purpose of this study was to develop a predictive ART approach for oropharyngeal squamous cell carcinoma
(OPC) and nasopharyngeal carcinoma (NPC) patients.
Methods
One hundred and ten patients with OPC or NPC were analysed. Patient demographics and tumour
characteristics were compared between patients who were replanned and those who were not. Factors
found to be significant were included in logistic regression models and risk profiles developed. Timing of
reimaging and separation change between patients who were replanned and those that were not was also
assessed.
Results
Nodal disease stage, pre-treatment largest involved node size, diagnosis and initial weight (categorised in 2
groups) were identified as significant factors (p<0.05). Two models were significant (p=0.001) and three ART risk
profiles were developed. Replanned patients had an earlier re-CT: median fraction 18 versus fraction 23
(p=0.01). Replanned patients had a significantly greater ipsilateral external contour reduction than those that
only had a re-CT (1.83 cm and 1.15 cm, p=0.02).
Conclusion
Development of a predictive approach identifying OPC or NPC patients more likely to require ART could
facilitate the effective implementation of ART into radiotherapy departments through forward planning and
appropriate resource allocation.



Oral health for patients receiving head and neck radiotherapy

Presenter: Janina Christoforou

Abstract
Radiotherapy to the head and neck region can result in a number of side-effects which can greatly reduce a
patient's quality of life. Some of these side-effects can be minimised or in some cases, even prevented with
appropriate management before, during and after radiotherapy.
This presentation will briefly look at the oral side-effects of head and neck radiotherapy and the benefits of oral
assessment and oral hygiene maintenance.

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The Harry Perkins Institute of Medical Research

6 Verdun Street

Nedlands, WA 6009

Australia

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