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Platinum Seminar-Prof. K. Swaminathan Iyer, The university of Western Austr...

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14All/Room E7 building 72

Monash University, Clayton Campus

Wellington Road

Clayton, VIC 3150

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Professor K. Swaminathan Iyer

The University of Western Australia

ARC Future Fellow and Leader: UWA-BioNano Initiative

Deputy HoS, School of Molecular Sciences

Title: Adaptive Redesign in Nanoscale Drug Delivery: Overcoming the Obstacles from Chemotherapy to Genome Engineering

The intelligent design of nanoformulations seek to expand upon the benefits of the first- generation, clinically tested delivery agents by adding functionalities intended to improve delivery, therapeutic efficacy, and ultimately patient outcome. Compared with delivering drugs or imaging agents alone, multimodal nanoformulations can simultaneously deliver imaging and therapeutic agents enabling detection and treatment of cancer in a single procedure. These agents are designed to help make informed decisions about timing, dosage, drug choice, and treatment strategies. However these delivery agents have to constantly evolve keeping in mind the enormous advances in the nature of the treatment modalities from small molecules to high precision genome engineering tools.
In this presentation, I will focus on the design and utility of a poly(glycidal methacrylate) [PGMA] based colloidal and dendritic nanoformulations both as a theranostic platforms and gene delivery agents for cancer therapy. I will highlight the necessity to incorporate an adaptive redesign strategy keeping in mind the type of cancer, delivery agents and the clinical relevance of the approach. Using four globally relevant cancer models (Brca2/p53- knockout breast cancer, Apc-deficient crypt progenitor colon cancer, castration-resistant prostate cancer and triple negative breast cancer), I will discus different modes of treatment (in-site injection, oral and intravenous administration) and most importantly the opportunities/challenges encountered by adopting this approach for treatment.

Bio: Iyer obtained his PhD. in Materials Science from Clemson University, South Carolina, USA. Following which he was awarded the presidents postdoctoral fellowship at Clarkson University, NY, USA in Biophysics where he developed the first Bio-Force AFM technology. Following his term in USA he relocated to UWA in 2006, where he now leads the WA BioNano Initiative. He has since then obtained 3 consecutive fellowships (ARC APD, QEII and Future Fellowship), total grant funding of > 17M, published over 150 papers, 5 international patents and formed a UWA- spin off company Eridan Technologies. His research group focuses on the use engineering innovative polymeric nanoformulations which are designed for the treatment of untreatable medical emergencies like traumatic brain injuries, traumatic burns injury, cardiovascular diseases, placental related disorders in pregnancy and cancers (breast, cervical, colorectal).

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14All/Room E7 building 72

Monash University, Clayton Campus

Wellington Road

Clayton, VIC 3150

Australia

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