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A vaccine to prevent heart attacks? What we can learn from old people.

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Westmead Institute for Medical Research (WIMR)

Seminar Room 2.20

176 Hawkesbury Road

Westmead

Australia

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A confluence of normal changes with age and underlying disease affects how old people differ from their younger counterparts in how they present clinically, what conditions they present with and the strategies that can affect these outcomes. Most clinical trials systematically exclude individuals with poorer health and often also individuals of advanced age. Yet, the oldest old, especially those that are too frail to live independently, both have the costliest and most severe outcomes, but also the greatest room for benefit from preventive strategies. Furthermore, the number needed to treat with an effective intervention for events that increase with age decreases. The discussion will present immunosenescence mechanistically in context with a series of data concentrating on elderly especially in the long-term care setting in the US, and important outcomes including hospitalisation and cardiovascular event attenuation with vaccination as an intervention.

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Westmead Institute for Medical Research (WIMR)

Seminar Room 2.20

176 Hawkesbury Road

Westmead

Australia

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